Excellent response, Bill. Your recommendations conform very closely to the specs on the 413 in my 300L (and may I also compliment you on your use of real sentences, with capital letters too!).
A few comments I would add:
-Be careful with hood clearance with the Performer RPM intake. I used the regular Performer intake for that reason (although I didn't check the clearance on the RPM). -With an auto transmission, I recommend a carb with vacuum secondaries. Then you can just mash the pedal off the line without any bogging. -I used a Holley "Street Avenger" 670 CFM on my 413. On a 440 a 750 CFM is probably plenty big unless you are going with a really big cam which would be a mistake for the street. -Think about using one of the latest design cams such as Comp Cams Xtreme Energy. They open & close the valves more quickly so you can use a shorter duration cam & get bigger-cam flow. -You can't get off-the-shelf headers to fit a C-body (at least not a '65). Custom is expensive. I swapped my stock exhaust manifolds for those off a 440 6-pack which flow better. If you are using stock exhaust manifolds, a 2 1/2" exhaust is redundant since the stock manifolds are restrictive. In that case I would use 2 1/4" pipes. Also the smaller pipes will reduce your exhaust sound level. -Get quiet mufflers. I first tried Flowmasters and they were way too loud! With a breathed-on big block, big pipes and a C-body you can get a lot of reverberation in the passenger compartment, especially when you lift off the throttle. -Install a 160 degree thermostat and make sure your cooling system is up to snuff. This gives a little more room to advance the timing. -I would keep the compression ratio around 9.5:1 with iron heads and a medium size cam. Then you can still add some timing and run on pump premium gas 92 octane. At 10:1 compression you'll probably have to back off on timing and/or use octane boost additive. -Install oil pressure and temperature gauges under the dash. Don't risk all that money in the motor on idiot lights.
Steve Galezowski 1965 300L